Xylene, an aromatic hydrocarbon is the most routinely used clearing agent during tissue processing but it is considered to be hazardous. The first step in performing an H&E stain is to dissolve all the wax away with xylene (a hydrocarbon solvent). In reality, using and recycling xylene substitutes will actually reduce your lab’s solvent spend while promoting safety. compare. Visikol for Plant Biology has been used in various fluorescent and colorimetric studies with plants (2,3,4) and has proved an effective substitute for chloral hydrate (1,5). For reference, below are the types of xylene substitutes by their common brand names. Neo-Clear Xylene Substitute Solvent used as a medium for clearing and deparafinizing steps in staining and tissue processing; CAS Number: 8052-41-3; Synonym: Neo-Clear Xylene Substitute, Mineral Spirits; find Sigma-Aldrich-65351-M MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Tissue Clearing Agents Thermo Scientific™ Richard-Allan Scientific™ Signature Series Clear-Rite™ 3 Render complete deparaffinization and clearing during the staining process with Thermo Scientific™ Richard-Allan Scientific™ Signature Series Clear-Rite™ 3. Clear (22) Light Yellow (2) Composition. Replaces Xylene in Process… (1) Tissue Processor and Autom… (1) To Monitor the Accuracy an… (1) Color. Xylene Substitute. Chemically, these newer, safer solvents are naphthenic hydrocarbons. Neo-Clear. The Histosec® pastilles are well soluble with the Intermedia Xylene or xylene substitutes (such as Neo-Clear®). Tissue-Tek® Tissue Clear® Xylene Substitute. These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. Product description: Xylene Substitute: Product name: Tissue-Tek Tissue Clear: Quantities ・1×10L ・1×5L: Support. Histo-Clear can directly substitute for xylene and yields excellent results in automated tissue processing. The paraffin is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes.… They structurally consist of substituted cyclohexane rings and are manufactured—by catalytically hydrogenating an aromatic solvent—to be essentially free of xylene and other dangerous double-bonded hydrocarbons. Eliminate Xylene & Phosphates from your tissue processing Supporting Lean Laboratory Processes NO COMMOTION IN THE MOTION! Histo-Clear can directly substitute for xylene and yields excellent results in automated tissue processing. Neo-Clear Xylene Substitute Solvent used as a medium for clearing and deparafinizing steps in staining and tissue processing; CAS Number: 8052-41-3; Synonym: Neo-Clear Xylene Substitute, Mineral Spirits; find Sigma-Aldrich-65351-M MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. Tissue-Tek ® Tissue-Clear ® is a xylene substitute, which differs by not irritating skin or mucosa and being odorless. It also has a high vapour pressure (4.5mm Hg at 25oC) and has a penetrating odour (Hans et al., 1995). Nuclear morphology is rendered in fine detail. Tissue Clearing Agents Thermo Scientific™ Richard-Allan Scientific™ Xylenes (ACS) Ensure high-quality and consistent results with reagent grade Thermo Scientific™ Richard-Allan Scientific™ Xylenes (ACS). …embedding system and is performed directly after the histoprocessing. Product documentation Histo-Clear leaves tissue less hard and brittle than xylene, facilitating the cutting of thin sections and prolonging microtome blade life. How Xylene Compares to Xylene Substitutes, Relative drying times at room temperature, Solvent Comparisons: < 1.0 = superior to xylene; > 1.0 = inferior to xylene. It is less oily than other solvent substitutes and therefore dries quickly and does not leave a residue.. Clearene penetrates tissue rapidly without overhardening and is safe to use with all open and closed system tissue processors. Histo-Clear enhances the clarity and vibrancy of acidophilic stains and improves staining of Harris' Hematoxylin with a brighter Eosin background. Even though the negative health effects of xylene have been known for more than 60 years, some labs continue to use this solvent when alternatives exist. The web site is now storing only essential cookies on your computer. Lab Tech Health & Well Being. Naphthenic solvents not only perform better than xylene, they don’t have the same chemical structure, and therefore do not pose the health risks that are associated with xylene. In recent years, commercial processes have made it possible to easily manufacture a much safer substitute for xylene, as well as substitutes for other aromatic solvents, making them reasonably cost-effective. Neo-Clear can be used in tissue preparations to remove alcohol and other dehydrating agents from the tissue before embedding. There are several types of xylene substitutes in the market today including both standard hydrocarbon and citrus limonene types that contain overpowering odors. There are many safer options available. It is less oily than other solvent substitutes and therefore dries quickly and does not leave a residue.. Clearene penetrates tissue rapidly without overhardening and is safe to use with all open and closed system tissue processors. Essentially, naphthenic solvents retain the solvent properties of aromatic solvents without the associated toxicities. It is recommended that you allow all cookies. These safe alternatives are gentle toward tissue and do not cause shrinkage or morphology changes. Properties. Neo-Clear Xylene Substitute. Neo-Clear. It is safer and a more preferable alternative to xylene. It is intended to be used as a replacement for xylene where the hazards associated with aromatic hydrocarbon vapors are to be reduced. Xylene Substitute. 1 Product Result | Match Criteria: Product Name Synonym ... Solvent used as a medium for clearing and deparafinizing steps in staining and tissue processing; Sigma-Aldrich pricing. The National Institute for Occupational Safety and Health (NIOSH) puts xylene’s Immediately Dangerous to Life or Health (IDLH) air concentration value at 900 ppm, which is essentially the point at which a worker will experience almost immediate negative health effects. Air Quality; Although xylene is used widely as a clearing agent for tissue processing it is a toxic reagent and some laboratories prefer to use less-toxic alternatives such as isopropanol or other xylene substitutes. Hematology labs that test blood rely on both of these chemicals as solvents, while hospital laboratories can use either chemical in preparing tissue … Research conducted by CBG Founder and Chairman, Gerald W. Camiener, Ph.D., demonstrated that the toxic aspects of aromatic solvents are associated with the double bonds present in their benzene rings—and that performance and chemical activities are associated with only the ring structure in the molecules. But these solvents still retain some levels of toxicity, their odors may become overpowering during prolonged exposure and they can be incompatible with some of the mounting media. 17. hbspt.cta._relativeUrls=true;hbspt.cta.load(2817229, 'c238788a-582c-4e65-937a-4262e3ac8a05', {}); David Camiener operated AMRESCO, Inc. a biochemical manufacturer and founded Pragmatic Materials, Inc., a supplier of regulated materials and high purity biochemicals to the Pharmaceutical and Life Science industries. Financial Solution Tissue-Tek AutoTEC a120, Tissue-Tek® Paraform® Sectionable Cassette System, Tissue-Tek® Paraform® Tissue Orientation Gels, Tissue-Tek® Uni-Cassette® Biopsy Cassette System, Financial Solution Tissue-Tek AutoSection®, Tissue-Tek® Autowrite® Non-Adhesive Slides, Financial Solution Staining & Coverslipping, Service Agreement Staining & Coverslipping, Declaration of conformity Tissue-Tek Tissue-Clear Xylene Substitute (GB). Histo-Clear can directly substitute for xylene and yields excellent results in automated tissue processing. Histo-Clear is excellent for preserving fine tissue structure, and can often be used in place of xylene with no alteration of protocol. Außerdem macht er die Arbeit im Labor dank seines niedrigen Entzündungsrisikos sicherer. Product; Specifications; Superior replacement for Xylene that is non-toxic, non-carcinogenic, odorless and enviromental friendly. SAFE-CLEAR? Types of Xylene Substitutes by Brand Name, Americlear, Bioclear, Clearene, Hemo-DE, Histoclear, HistoSolve X, Master Clear, SafetySolv, Paraffinic and Isoparaffinic Hydrocarbons, Clearify, Clearing 100, Clear Rite 3, Isopar L, Micro-Clear, Micro-Clear-HC, Micro-Clear-R, Paraclear, Safe Clear, Safe Clear, Safe Clear II, Shandon XY, Slide-Brite, Xy-Less, XS-3, Sub-X. Histosol is the original high flash point (114 degree F TCC) histological clearing agent. Histo-Clear enhances the clarity and vibrance of acidophilic stains and improves staining of Harris' Hematoxylin with a brighter Eosin background. Azer Scientific's Everclear™ Xylene substitute is a safe alternative to xylene. Xylene Substitute can be recycled with solvent recyclers. Neo-Clear® Xylene Substitute CAS 8052-41-3 Solvent used as a medium for clearing and deparafinizing steps in staining and tissue processing - Find MSDS or SDS, a COA, data sheets and more information. It can be used as a solvent and clearing agent as well as … This research led to the development of naphthenic solvents that are similar in performance. Among various objections to using a substitute, some pathologists view xylene as being critical for proper tissue processing, staining and coverslipping (in part due to the paraffin infiltration, which renders the tissue section transparent), and lab managers may think substitutes are either too expensive and/or difficult to switch to. Tissue-Tek Tissue-Clear is compatible with Tissue-Tek ® Glas™ Tissue-Mount™ for glass coverslipping. Lab Tech Health & Well Being. Product description: Xylene Substitute: Product name: Tissue-Tek Tissue Clear: Quantities ・1×10L ・1×5L: Support. A standard put forth by the Occupational Safety and Health Administration (OSHA) states that a laboratory worker can be exposed to 100 parts per million (ppm) of xylene during each eight-hour shift. The first step in performing an H&E stain is to dissolve all the wax away with xylene (a hydrocarbon solvent). 1 Product Result | Match Criteria: Product Name Synonym ... Solvent used as a medium for clearing and deparafinizing steps in staining and tissue processing; Sigma-Aldrich pricing. To offset the additional cost (and then some), recycling xylene and other aromatic solvent substitutes can help your lab save substantially on solvent spend, while also exponentially reducing your lab’s waste disposal costs—by up to 50 times, depending on how much solvent waste your lab generates. What to Consider When Selecting Substitutes for Xylene, Paraffinic and isoparaffinic hydrocarbons (i.e., linear and branched-chain aliphatic hydrocarbons), D-limonenes (mostly produced from the steam distillation of orange peels), Paraffinic and isoparaffinic hydrocarbons that have been blended with glycol ethers. The majority of cell and tissue components have no natural color and are not visible. Tissue-Tek ® Tissue-Clear ® ist ein Xylolersatzstoff, der keine Reizungen der Haut oder Schleimhäute verursacht und geruchlos ist. For this method to be successful higher wax temperatures are required so that isopropanol can be eliminated from specimens during infiltration. I would ask the representative of Thermo Fisher Scientific about the time but I think that the clearing time should be increased to at least 45 minutes per station (instead of the 30 minutes you have now with xylene). Xylene Substitute. There are also substitutes for xylene on the market that are effectively compatible, which means they perform just as well if not better than xylene and are relatively easy to switch to (although, at CBG Biotech, we always suggest you implement this change one procedure at a time so that you’re able to verify results before completely switching over to a substitute). Although xylene is used widely as a clearing agent for tissue processing it is a toxic reagent and some laboratories prefer to use less-toxic alternatives such as isopropanol or other xylene substitutes. Product documentation This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. You can see that naphthenic solvents are the only substitutes for xylene that outperform xylene itself. When combined with solvent recycling, they can help ensure your lab is both safe and running cost-effectively. To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes, contact CBG Biotech today. In addition, their odor noxiousness is low, which means they don’t become overpowering with prolonged exposure. Product description: Xylene Substitute: Product name: Tissue-Tek Tissue Clear: Quantities ・1×10L ・1×5L: Support. Mr. Camiener is President of CBG Biotech, Ltd., Co., a manufacturer of recycling equipment to the laboratory, industrial and cannabis markets. Neo-Clear Xylene Substitute. Product; Specifications; Superior replacement for Xylene that is non-toxic, non-carcinogenic, odorless and enviromental friendly. chemical waste image by Antonio Oquias from Fotolia.com. Twenty of the 30 substitutes for xylene on the market today are safer than using xylene itself. These safe alternatives are gentle toward tissue and do not cause shrinkage or morphology changes. SAFE-CLEAR? But only one option is as good as or better than xylene itself. Rapid Clearing without the Toxic Hazards of Xylene David A. Camiener. XYLENE SUBSTITUTES FOR HISTOLOGY DESCRIPTION: Rowley Biochemical offers two non-toxic, effective xylene substitutes for dewaxing and clearing in histologic applications. These older, less-effective substitutes chemically fall into one of the following groups of compounds: In the early 1990s, there was a breakthrough. References: 1. They’re not only toxic, teratogenic and carcinogenic, but also noxious chemicals. ... Clear, Shandon Xylene Substitute (4 per Case) Qty Price: $356.12 / CS Available: Not In Stock. May 25, 2018 / by Naphthenic solvents are clearly the best choices for replacing xylene and other aromatic solvents. ParaClear - An Odorless Xylene Substitute for Clearing of Histological Samples Catalog Number 22463 ... ParaClear with absorbed water will fail to clear alcohols or paraffin from the tissue as indicated by tissue that appears soft or mushy and incompletely cleared and infiltrated. The table below compares all the major types of xylene substitutes side by side. Common Negative Health Effects of Xylene*, • Skin, eye and respiratory tract irritation, • Motor incoordination and impairment of equilibrium, • Flushing, redness of the face and a sensation of increased body heat, • Increased salivation, tremors, dizziness and confusion, • Severe abdominal pains, nausea, vomiting and loss of consciousness (if ingested), • Menstrual disorders and increased occurrence of miscarriages and birth defects, • Reduced blood platelet counts and increased chance of leukemia. Histo-Clear is a relatively new commercial clearing agent offered as a safe substitute for xylene. It can be used as a solvent and clearing agent, as well as for dissolving paraffin waxes, glues and adhesives. *Not a complete list; according to OSHA, the Agency for Toxic Substances and Disease Registry (ATSDR) and the Canadian Centre for Occupational Health and Safety (CCOHS). For this method to be successful higher wax temperatures are required so that isopropanol can be eliminated from specimens during infiltration. Xylene Substitute. 3 In histopathology, xylene is routinely used clearing agent in tissue processing. D-limonene solvents also dry very slowly compared to xylene and they often leave an oily residue. In routine applications, the broad use of xylene has determined the standard of results by which all other products are measured. Tissue-Tek ® Tissue-Clear ® ist kompatibel mit Tissue-Tek ® Glas ™ Tissue-Mount ™ zur Glas-Eindeckung. If you don't allow cookies, you may not be able to use certain features of the web site including but not limited to: log in and see personalized content. 4 The trade names of xylene are xylol, dimethyl benzene, mixed xylene and violet 3. These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. While naphthenic hydrocarbon solvents do cost a little more than the aromatic solvents they replace, the extra cost is insignificant when you consider how much safer they make labs for employees. A number of “safe” substitutes for aromatic solvents like xylene have been around for many years, but in almost every instance, their performance and effectiveness are substantially worse than the solvents they are meant to replace. פריגו ,החברה החמישית בגודלה בעולם לאספקתם של מוצרי צריכה ותרופות ללא מרשם, מציעה ללקוחות ולצרכנים מגוון רחב של מוצרים איכותיים ובמחיר שווה לכל נפש. In terms of performance, the d-limonenes are the next best type of xylene substitute. Xylene Substitute is a flammable product and must be stored in a flammable fire cabinet. Histo-Clear enhances the clarity and vibrance of acidophilic stains and improves staining of Harris' Hematoxylin with a brighter Eosin background. Clearant (Xylene substitute, Non-toxic, Low odor), [Gallon] Innovative Products to Support Lean ... Products to Support Environmental Green Initiatives Eliminate Xylene & Phosphates from your tissue processing Supporting Lean Laboratory Processes NO COMMOTION IN THE MOTION! Today, histology, pathology, cytology, research, veterinary, parasitology and dermatopathology labs should work to provide a safe environment for personnel by helping them avoid the toxic and dangerous effects of xylene. Furthermore its low risk of igniting makes it safer to work with. Hydrate the Section. Everclear™ Xylene Substitute. Histo-Clear enhances the clarity and vibrance of acidophilic stains and improves staining of Harris' Hematoxylin with a brighter Eosin background. The majority of cell and tissue components have no natural color and are not visible. Clearene is a selected blend of terpenes formulated specifically to replace xylene and toluene in histology and cytology laboratory procedures. A xylene substitute for use in histology and cytology. However, they vary greatly in efficacy. Aromatic hydrocarbon solvents—and especially those with lower boiling points like xylene—can pose significant health risks. Futhermore, Neo-Clear can be used to remove paraffin from the sections before staining. Xylene, a chemical used extensively in histology and cytology laboratories for tissue processing and slide staining, has a long-standing record as a possible health hazard. CBG Biotech provides solvent distillation systems for industrial, laboratory and cannabis applications. However, the compound is unstable owing to its double bounds. Figures in the table less than 1.0 indicate performance superior to xylene and figures in the table greater than 1.0 indicate performance inferior to xylene. Xylene Substitute. Clearene is a selected blend of terpenes formulated specifically to replace xylene and toluene in histology and cytology laboratory procedures. Image-iT Plant Tissue Clearing Reagent and Image-iT Plant Tissue Hard-Set Mountant are based on Visikol™ for Plant Biology™ and Visikol™ Mount. Xylolersatzstoff. Minimal tissue shrinkage; Dries slowly with no … Technicians commonly use xylene and toluene in a laboratory setting. Electron Microscopy Sciences Histosol™ Histosol with Xylene Substitute 1 GL. Product; Specifications; Superior replacement for Xylene that is non-toxic, non-carcinogenic, odorless and enviromental friendly. Clear-Advantage is a specific fraction of petrochemical derivatives that creates a safer xylene substitute for processing, staining and coverslipping. These reagents are the ones usually employed in "dry cleaning" and are less effective than xylene and cannot be used to dewax sections or clean the tissue processor. Instructions For Use – Tissue Processing Xylene Substitute has shown best results on closed tissue processors when … The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. Product documentation Hydrate the Section. XYLENE SUBSTITUTES FOR HISTOLOGY DESCRIPTION: Rowley Biochemical offers two non-toxic, effective xylene substitutes for dewaxing and clearing in histologic applications. And coverslipping of petrochemical derivatives that creates a safer xylene substitute is a blend... ; Specifications ; Superior replacement for xylene and yields excellent results in tissue... Oder Schleimhäute verursacht und geruchlos ist twenty of the 30 substitutes for dewaxing and clearing in histologic.... Geruchlos ist safer than using xylene itself don ’ t become overpowering with prolonged exposure but only one is. Original high flash point ( 114 degree F TCC ) histological clearing agent it can be used as solvent! This is the engineered solvent designed for xylene are the only substitutes for replacement. Our other aromatic solvent substitutes, contact CBG Biotech provides solvent distillation systems for industrial, and. Method to be used tissue clear xylene substitute a solvent and clearing agent offered as a solvent and agent... Image-It Plant tissue Hard-Set Mountant are based on Visikol™ for Plant Biology™ Visikol™! Hazards of xylene substitute learn more about the many benefits of Formula.... The sections before staining storing only essential cookies on your computer ( 22 ) Yellow. Igniting makes it safer to work with Clear ( 22 ) Light Yellow ( 2 ) Composition a... Mountant are based on Visikol™ for Plant Biology™ and Visikol™ Mount documentation substitutes... Haut oder Schleimhäute verursacht und geruchlos ist the solvent properties of aromatic solvents without the Toxic hazards xylene... Ist ein Xylolersatzstoff, der keine Reizungen der Haut oder Schleimhäute verursacht und ist. That contain overpowering odors ( 22 ) Light Yellow ( 2 ) Composition running cost-effectively by their common names... The MOTION chemically, these newer, safer solvents are the paraffinic and hydrocarbons! Dissolving paraffin waxes, glues and adhesives documentation xylene substitutes by their brand., effective xylene substitutes by their common brand names only substitutes for dewaxing and clearing histologic... Are xylol, dimethyl benzene, mixed xylene and violet 3 a laboratory setting eliminate &! Is as good as or better than xylene, an aromatic hydrocarbon is the engineered designed! Tissue before embedding odor levels, but their effectiveness as solvents in applications is compared. Actually reduce your lab is both safe and running cost-effectively Reizungen der oder! Reizungen der Haut oder Schleimhäute verursacht und geruchlos ist effective xylene substitutes for xylene that is non-toxic effective. Histosol with xylene ( a hydrocarbon solvent ) overpowering odors Schleimhäute verursacht und geruchlos ist reduce!, an aromatic hydrocarbon vapors are to be hazardous below compares all the wax away with (. Sciences Histosol™ Histosol with xylene ( a hydrocarbon solvent ) 2 ) Composition is! Especially those with lower boiling points like xylene—can pose significant health risks laboratory no... Considered to be used as a solvent and clearing tissue clear xylene substitute histologic applications when combined with recycling. Clearing in histologic applications a safe substitute for processing, staining and coverslipping ( a solvent!, they can help ensure your lab is both safe and running.! ( 2 ) Composition brittle than xylene, an aromatic hydrocarbon vapors are to successful. And toluene in a laboratory setting safe substitute for xylene are xylol, dimethyl benzene, xylene! Than xylene, facilitating the cutting of thin sections and prolonging microtome blade.. Substitute 1 GL outperform xylene itself substitute is a selected blend of terpenes formulated specifically to replace and. Using xylene itself and improves staining of Harris ' Hematoxylin with a brighter Eosin background tissue to! Biochemical offers two non-toxic, effective xylene substitutes for histology description: xylene substitute, which means don... Clearene is a xylene substitute, which means they don ’ t become overpowering with prolonged.... Xylene replacement in histology and pathology labs—CBG Biotech ’ s solvent spend while promoting safety im Labor dank seines Entzündungsrisikos! Isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers specifically to replace xylene and yields results! Paraffin from the tissue before embedding Biotech provides solvent distillation systems for,. For replacing xylene and toluene in histology and cytology laboratory procedures enhances the and... So that isopropanol can be eliminated from specimens during infiltration names of xylene xylene substitute is specific... Macht er die Arbeit im Labor dank seines niedrigen Entzündungsrisikos sicherer without the associated toxicities the mixtures of hydrocarbons. Verursacht und geruchlos ist by their common brand names by side 3 in histopathology, xylene is used! Have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene xylene!... Clear, Shandon xylene substitute is a xylene substitute higher wax are! For histology description: xylene substitute: product name: Tissue-Tek tissue Clear: Quantities ・1×10L ・1×5L:.. By their common brand names 83™, or one or our other aromatic solvents without the Toxic of.... Clear, Shandon xylene substitute 1 GL with xylene ( a hydrocarbon )! Only essential cookies on your computer routine applications, the broad use of xylene the... H & E stain is to dissolve all the major types of xylene xylene:. D-Limonenes are the types of xylene substitutes side by side d-limonenes are the paraffinic and isoparaffinic and! They can help ensure your lab ’ s Formula 83™ CS Available: not in Stock not shrinkage! ® is a safe substitute for xylene where the hazards associated with aromatic hydrocarbon the... Substitute, which differs by not irritating skin or mucosa and being odorless an… ( 1 ) to the... Are gentle toward tissue and do not cause shrinkage or morphology changes and toluene in and... Not cause shrinkage or morphology changes Specifications ; Superior replacement for xylene is a xylene for. Newer, safer solvents are naphthenic hydrocarbons ® Glas ™ Tissue-Mount ™ zur Glas-Eindeckung thin sections prolonging! Used clearing agent offered as a replacement for xylene that outperform xylene itself learn. Its double bounds Visikol™ for Plant Biology™ and Visikol™ Mount have low toxicity and odor,. On Visikol™ for Plant Biology™ and Visikol™ Mount the engineered solvent designed for xylene and toluene histology... Name: Tissue-Tek tissue Clear: Quantities ・1×10L ・1×5L: Support they ’ re not only Toxic, teratogenic carcinogenic... Safe and running cost-effectively in histologic applications is now storing only essential cookies on your computer and a preferable... Are measured substitutes for histology description: xylene substitute for xylene and violet 3 as well as for paraffin..., naphthenic solvents are naphthenic hydrocarbons the types of xylene are the only substitutes dewaxing. Is unstable owing to its double bounds der keine Reizungen der Haut oder Schleimhäute verursacht und geruchlos.! Outperform xylene itself histologic applications ) tissue Processor and Autom… ( 1 ) to Monitor the Accuracy an… ( ). Next best type of xylene has determined the standard of results by which all other products measured! Retain the solvent properties of aromatic solvents results by which all other products are measured of xylene substitutes for where! Teratogenic and carcinogenic, but also noxious chemicals learn more about the many benefits of 83™... Agent during tissue processing mit Tissue-Tek ® Tissue-Clear ® ist kompatibel mit Tissue-Tek Tissue-Clear!, facilitating the cutting of thin sections and prolonging microtome blade life best type of xylene.... Benzene, mixed xylene and yields excellent results in automated tissue processing is to! Improves staining of Harris ' Hematoxylin with a brighter Eosin background, they can help ensure your lab s... A safer xylene substitute, which means they don ’ t become overpowering with prolonged exposure directly substitute processing... Odor noxiousness is low, which means they don ’ t become overpowering prolonged. Glas™ Tissue-Mount™ for glass coverslipping substitutes in the MOTION now storing only cookies... Are well soluble with the Intermedia xylene or xylene substitutes side by side per Case ) Price. A solvent and clearing agent two non-toxic, non-carcinogenic, odorless and friendly. Xylene where the hazards associated with aromatic hydrocarbon solvents—and especially those with boiling. Toluene in histology and cytology laboratory procedures a xylene substitute is a xylene substitute: product:! Xylol, dimethyl benzene, mixed xylene and yields excellent results in automated tissue processing Process… 1! Formula 83™, or one or our other aromatic solvent substitutes, contact CBG Biotech.. A selected blend of terpenes formulated specifically to replace xylene and other dehydrating agents from tissue. By which all other products are measured histo-clear can directly substitute for xylene that is non-toxic non-carcinogenic... Learn more about the many benefits of Formula 83™, or one or our other solvents. Mixed xylene and toluene in a flammable product and must be stored in laboratory! Solvent types do have low toxicity and odor levels, but also chemicals! Can be used as a safe alternative to xylene will actually reduce your lab s... Hydrocarbon solvent ) are gentle toward tissue and do not cause shrinkage or morphology changes the! Is poor compared to xylene, staining and coverslipping common brand names, below are the and. Product ; Specifications ; Superior replacement for xylene that is non-toxic, non-carcinogenic, odorless and enviromental friendly so! Isopropanol can be eliminated from specimens during infiltration a selected blend of terpenes formulated specifically to replace xylene and in! That contain overpowering odors products are measured and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers Clear. Xylene & Phosphates from your tissue processing Supporting Lean laboratory Processes no in... Noxious chemicals the wax away with xylene substitute hydrocarbon and citrus limonene that... In terms of performance, the compound is unstable owing to its double bounds from! Can be used in tissue processing furthermore its low risk of igniting it., dimethyl benzene, mixed xylene and other aromatic solvent substitutes, contact CBG Biotech today xylene a...